El Shaarawy and Diego Perotti are expected to flank centre-forward Edin Dzeko, leaving Patrik Schick on the bench.
Nonetheless, Sky Sport Italia suggest La Joya will be sent to the bench yet again, as he doesn’t fit in the new 4-3-3 system alongside Gonzalo Higuain.
Eusebio Di Francesco rarely strays from his beloved 4-3-3 system but, unlike mentor Zdenek Zeman, he makes sure the defence is solid.
Mandzukic and Juan Cuadrado have shaken off injuries, sending Douglas Costa and Federico Bernardeschi back to the bench.
It kicks off at 19.45 GMT,
Juventus could also push Andrea Barzagli to right-back, in effect a three-and-a-half-man defence, often used in the Ch皇冠外围投注ampions League.
Dybala was dropped for two Serie A rounds in a row and broke his goal drought in the Coppa Italia win over Genoa midweek.
Max Allegri is keeping everyone guessing, as he is without Gigi Buffon, Mattia De Sciglio and Benedikt Howedes, so Wojciech Szczesny starts against his old club.
There are growing reports Paulo Dybala will be benched for the third Serie A game running, as Juventus host Roma tonight.
In fact, they have the best defensive record in Serie A this season, while 真人外围投注Juve are the most prolific in attack.
Roma (probable): Alisson; Florenzi, Manolas, Fazio, Kolarov; Nainggolan, De Rossi, Strootman; El Shaarawy, Dzeko, Perotti
Juventus (probable): Szczesny; Barzagli, Benatia, Chiellini, 六合投注网站Alex Sandro; Pjanic, Khedira, Matuidi; Cuadrado, Higuain, Mandzukic
Roma are missing Gregoire Defrel and Rick Karsdorp, but otherwise have a full squad to choose from.
Alessandro Florenzi should get the right-back spot with Daniele De Rossi available again after suspension.
This is a Scudetto showdown, as Juve are currently in second place and the Giallorossi are fourth, but with a game in hand.