It kicks off at San Siro on Sunday at 17.00 GMT,
Immobile is the Capocannoniere of Serie A with 20 goals, but he limped off during last week’s 5-1 victory over Chievo.
Ciro Immobile is expected to only be on the bench when Lazio visit Milan on Sunday evening due to injury.
However, Immobile skipped this morning’s training session and is therefore expected to be on the bench at best.
With Felipe Caicedo also sidelined, Felipe Anderson should take the centre-forward role with support from Luis Alberto.
Another alternative would be Luis Nani, who was on target midweek against Udinese.
He missed Wednesday’s rescheduled tie with Udinese, a 3-0 win, and should be b澳门外围投注ack in the squad for this weekend.
Curiously, Milan and Lazio face off again next week in Tuesday’s 网络外围投注Coppa Italia semi-final, first leg fixture.