Sassuolo have won three 在线外围投注on the bounce, including a shock victory over Inter before Christmas.
They have a surprisingly good record at the Olimpico, drawing three of their previous four visits.
It kicks off at 14.00 GMT,
Claud Adjapong, Stefano S21点官网ensi, Davide Biondini and Timo Letschert are on the treatment table, but the big news is th网上21点at Berardi isn’t even on the bench after an injury in yesterday’s training session.
They are also fourth in Serie A with a game in hand, but have slowed down a little lately with just two wins in the last five rounds.
The Neroverdi struggled at the start of the post-EDF era, but after sacking Cristian Bucchi to bring in Beppe Iachini, they have been a revelation.
There's a final run-out for Paolo Cannavaro, his last game before retiring to join brother Fabio in China.
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Pellegrini, De Rossi, Nainggolan; Schick, Dzeko, Perotti
It’s a reunion for former Sassuolo midfielder Lorenzo Pellegrini too, while there are reports Berardi and Matteo Politano could be heading the other way in 2018.
Antonino Ragusa steps into the trident attack with Diego Falcinelli and Politano.
Sassuolo: Consigli; Lirola, Cannavaro, Acerbi, Peluso; Missiroli, Magnanelli, Duncan; Politano, Falcinelli, Ragusa
Gregoire Defrel is out injured against his old club, joined by Rick Karsdorp, but Schick gets the nod in attack with Edin Dzeko and Diego Perotti.
Di Francesco has gone from strength to strength since taking over at the Stadio Olimpico, topping the Champions League group and securing a spot in the Coppa Italia Quarter-Final.
Eusebio Di Francesco relies on Patrik Schick against his former club, but Sassuolo are without Domenico Berardi due to injury.